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Drug−Protein Adducts: An Industry Perspective on Minimizing the Potential for Drug Bioactivation in Drug Discovery and Development | Chemical Research in Toxicology

To enhance their effectiveness, polyethylene glycol was attached to antioxidant enzymes (pegylated SOD and/or pegylated CAT), an approach shown to increase their in vivo half-lives, cellular uptake by endothelial cells, and effectiveness in preventing pulmonary oxygen toxicity in rats [119, 120]

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