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The energy demands of endocrine tissue as well as redox reactions involved in the production and release of factors require selenoproteins such as GPXs and TRXRs to prevent accumulation of ROS

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Nature Medicine Contributors: Jiseung Kang, Hyeon Jin Kim, Min Seo Kim, GBD 2023 Substance Use Collaborators (including Shankargouda Patil), Jae Il Shin, and Dong Keon Yon January 16, 2026 “Global, regional, and national burden of chronic respiratory diseases and impact of the COVID-19 pandemic, 1990–2023: a Global Burden of Disease study”