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coli cytosol can be explained by its intense thiophilicity, which is sufficient to competitively disrupt key cytoplasmic iron-sulfur enzymes both in vitro and in vivo (Macomber and Imlay, 2009)

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The role of modulators of the GABAergic system, including selective partial agonists of specific GABAA receptor subunits (such as α2 and α3), which could improve cognitive function without the adverse effects of benzodiazepines, has also been investigated [157]