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It is important to note that a highly electrophilic metabolite has a tendency to react with tissue nucleophilic groups such as -OH, -NH 2 and -SH and precipitate toxicities such as tissue necrosis, carcinogenesis, mutagenesis, teratogenesis, etc

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[DOI] [PubMed] [Google Scholar] 111.Balercia G., Buldreghini E., Vignini A., Tiano L., Paggi F., Amoroso S., Ricciardo-Lamonica G., Boscaro M., Lenzi A., Littarru G