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Reduced activities of GPx, one of the most important antioxidant defence system in the body, were reported either increased or reduced in different tissues as intracellular antioxidant enzymes (25, 27)

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This multifaceted role of Nrf2 in both cancer and neurodegenerative disorders highlights its significance as a key regulator of cellular health and stress response, making it an important target for therapeutic interventions in various pathological conditions