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Other medications that may affect B12 status include colchicine (used for gout), which can impair intestinal absorption, and nitrous oxide (used in anaesthesia and increasingly misused recreationally), which irreversibly inactivates B12 by oxidising the cobalt ion in its structure

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A comprehensive review of free radicals, oxidative stress, and antioxidants: Overview, clinical applications, global perspectives, future directions, and mechanisms of antioxidant activity of flavonoid compounds