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Direct in vitro comparisons of these mAbs showed comparable antibody-dependent cell-mediated toxicity (ADCC) and binding affinities, but remarkable differences in the ability to induce direct apoptosis, to induce complement-mediated cytotoxicity (CDC), to inhibit enzymatic activities, and to induce antibody-dependent cell-mediated phagocytosis (ADCP)(Figure 2 and Table 12)[41-42]
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