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A lot of interventions that produce weight loss in animal models do so partly at the expense of muscle tissue, which is a real limitation when extrapolating toward any eventual human application

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▼ NNMT enzyme inhibition occurs within 2–4 hours of subcutaneous dosing based on pharmacokinetic modelling, but downstream metabolic effects — NAD+ elevation, changes in fat oxidation markers — typically require 2–4 weeks of consistent dosing to manifest in measurable endpoints