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Lipid peroxidation product 4-hydroxy-2-nonenal promotes seeding-capable oligomer formation and cell-to-cell transfer of α-synuclein

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listed as a bulk drug substance under evaluation for 503A compounding (2024) Route of administration / subcutaneous injection, intramuscular injection, or oral (in research settings) Typical research dose / 250 to 500 mcg once or twice daily in 4 to 8 week cycles Key research group / University of Zagreb Department of Pharmacology (Sikiric lab) Publication volume / over 100 peer-reviewed papers, predominantly from a single research group Discovery in Human Gastric Juice BPC-157 traces its origin to the late 1980s, when Predrag Sikiric and colleagues at the University of Zagreb identified a protein fraction in human gastric juice that displayed cytoprotective properties in stomach ulcer models 1