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A 2004 study in Journal of Pharmacology and Experimental Therapeutics showed that KPV at 1 mg/kg intraperitoneally reduced colonic TNF-alpha by 61% and IL-6 by 54% compared with vehicle in DSS-induced colitis in mice [13]
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In the phase 3 REDEFINE 1 trial, the combination of cagrilintide and semaglutide yielded a mean 20% reduction in body weight over 68 weeks in adults with overweight or obesity, significantly outperforming placebo and either agent alone
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