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Consider earlier administration (3+ hours before bed) to allow cortisol-modulating effects to establish before sleep pressure builds

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somniferum tyrosine decarboxylase 1 (TyDC1), which was modeled based on the structure of Sus Scrofa DDC in complex with carbidopa (PDB ID: 1JS3) 24 , contains a leucine residue at the position corresponding to AAAD active site His192 (Fig