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The conclusion is that the trispecific SAR442257 operates via dual targeting of CD38 and CD28 on myeloma cells and of CD3 and CD28 on T lymphocytes, showing superior MM killing compared to bispecific antibodies

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Potentiation of ACh release through transcutaneous vagal neuromodulation is known to enhance gut motility, reduce inflammation by suppressing TNF- α , and preserve epithelial tight junction integrity through the activation of enteric glial cells (243)