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doi: 10.1038/cddis.2010.64

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Luteolin induces apoptosis by regulating the expression of Bax and Bcl-2, promoting the release of cytochrome c, increasing the activity of caspase-9 and caspase-3, and increasing the level of reduced glutathione and the expression of GSH synthase, which is mediated by mitogen-activated protein kinase signaling pathway ( in vitro and in vivo , and enhanced the sensitivity of colon cancer cells to ferroptosis by reducing the expression of antioxidant enzyme GPX4 and up-regulating the expression of tumor suppressor HIC1 (Zheng et al., 2023)