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In cyclic-AMP accumulation assays, semaglutide displayed full agonism with an EC 50 in the low-nanomolar range, and β-arrestin recruitment indicated balanced downstream signaling
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Individuals with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia type 2 (MEN2) should discuss this with their clinician before considering any GLP-1–based therapy, and should be alert to symptoms such as a neck lump, hoarseness, or difficulty swallowing
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