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Indications: Guanethidine is “no longer available” in the USA due to lack of availability, but is available in the UK (wikipedia) Was used for severe cases of hypertension, either alone or as an adjunct drug Contraindications: Guanethidine can cause a hypertensive crisis in patients with pheochromocytoma due to the release of catecholamines (tyramine like action)

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SBP2 deficiency syndrome Selenocysteine insertion sequence binding protein 2 (SECISBP2