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Because MOTS-C is an endogenous exercise-responsive peptide, aerobic and resistance training naturally supports MOTS-C signaling

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Therefore, based on the in vitro and in vivo studies mentioned above, glutamine supplementation could be one promising candidate for treating intestinal inflammatory disorders by inhibiting activation of NF-κB and STAT, and suppressing expression of inflammatory cytokines such as IL-6, TNF-α, and IL-8, and inflammatory enzyme inducible NO synthase