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found that transected New Zealand rabbit Achilles tendons treated with focused ultrasound with targeted bFGF plasmid-loaded cationic microbubbles showed superior wound healing, smooth Achilles tendons, and non-adhesion to surrounding tissues ( In vitro animal studies have shown that bFGF is a powerful mitotic cell growth factor that multiplies and differentiates mesenchymal stem cells (MSCs) into tendon cells via the MAPK pathway (Figure 3 shows the role of bFGF on TSCs, MSCs, as well as fibroblasts and other growth factors