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To improve the bioavailability of dextromethorphan, it has been investigated in conjunction with quinidine, a potent inhibitor of cytochrome P450 2D6 that prevents the metabolic degradation of dextromethorphan into dextrorphan [105]
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𝐈𝐧 𝐭𝐡𝐞 𝐰𝐚𝐤𝐞 𝐨𝐟 𝐒𝐡𝐞𝐟𝐚𝐥𝐢 𝐉𝐚𝐫𝐢𝐰𝐚𝐥𝐚’𝐬 𝐮𝐧𝐭𝐢𝐦𝐞𝐥𝐲 𝐩𝐚𝐬𝐬𝐢𝐧𝐠, 𝐭𝐡𝐞 𝐢𝐧𝐭𝐞𝐫𝐧𝐞𝐭 𝐢𝐬 𝐟𝐥𝐨𝐨𝐝𝐞𝐝 𝐰𝐢𝐭𝐡 𝐬𝐩𝐞𝐜𝐮𝐥𝐚𝐭𝐢𝐨𝐧—particularly about glutathione
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