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Hydroxocobalamin IV. Biological Half-Life of Hydroxocobalamin in the Human Liver - ScienceDirect
People with gastrointestinal conditions : Individuals with conditions such as Crohn’s disease, celiac disease, or those who have undergone gastrointestinal surgery are at higher risk of B12 deficiency
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Similarly, certain variants of UGT1A1 , particularly UGT1A128 , can reduce the metabolism of the active irinotecan metabolite SN-38 and increase the risk of irinotecan-related toxicity
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