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The advantages and disadvantages of these therapies are summarized in Table 1

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It was noticed that a short period of CR (2 months) in rats significantly increased the activity of mitochondrial (but not of cytosolic) SOD and GPX activity (Judge et al., The protective effect induced by 6 months of CR on mitochondria also involved the regulation of SIRT3 (i.e., NAD-dependent deacetylase sirtuin-3), a mitochondrial deacetylase (Qiu et al., 2011)