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Interestingly, LIF can inhibit the production of the pro-inflammatory cytokine TNF-α and reactive oxygen species (ROS) by macrophages probably limiting a progression of inflammation and acting anti-apoptotic (Hendriks et al., 2008)

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It does however make perfect sense in theory and there are plenty of anecdotal reports of supplementing having a noticeable effect on the negative after-effects of MDMA (‘ecstacy’) use