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In studies of another intracellular pathogen, Leishmania , type 1 and 2 responses are cross-regulated and the absence of effector memory cells results in infection establishment ( It is important to wonder that if the mouse model is not able to predict persistence of bacteria in tissue, what conclusions can be drawn from the induced immune responses in the mouse model
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As CoPP structurally mimics heme but cannot be efficiently degraded by HO-1, CoPP treatment has been proposed as a potential therapeutic strategy for oxidative stress-related diseases, including cardiovascular disease 65,66 , diabetes 67 , obesity 68 , septic insults 65 , and metabolic syndrome 69
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