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Long-term, PV may progress to myelofibrosis (spent phase) or acute myeloid leukemia (AML) in ~10–20% of patients over 20 years

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Peptide Cyclization and Polyethylene Glycosylation Cyclization is a chemical method used in peptide delivery to enhance stability by removing exposed N- and C-termini, which are particularly susceptible to enzymatic degradation [69]