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Glutamine is a neutral amino acid and thus does not induce a negative charge burden in the mitochondrial matrix, which is already more negatively charged than the cytosol

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This is critical because droplet size determines where in the nasal cavity the drug deposits: droplets in the appropriate size range (typically 30–200 μm for nasal sprays) deposit in the nasal turbinates, where absorption occurs, while excessively small droplets may penetrate to the lower respiratory tract, and excessively large droplets may not clear the nasal vestibule

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