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As examples, some of these predictions are stated here: Under conditions of B12 insufficiency, excess folic acid intake will cause the following: Diversion of holoTC from serum to hemopoietic cells to support reticulocyte proliferation Loss of holoTC in urine due to interference of its reuptake by the megalin-receptor complex in the renal tubules Reduced availability of holoTC to the liver, brain, and other tissues due to its diversion to the hemopoietic system and loss in the urine

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[DOI] [PMC free article] [PubMed] [Google Scholar] 4.Gwyer D, Wragg NM, Wilson SL