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Thus, substrate profiling not only revealed the increased specificity of X(GD) proteases compared to wild-type BoNT/X and X(PC) variants but also uncovered a potential exosite interaction conserved from wild-type BoNT/X and retained in evolved gasdermin D-cleaving variants
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NTZ-elicited hepatoprotective effects are suggested to be mediated via modulation of PERK/CHOP10 signaling along with attenuated proapoptotic oxidative stress and proinflammatory signaling
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