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Rolfe, 2014) and can be used in melasma (Navarrete-Solís et al., 2011) and hyperpigmentation (Kimball et al., 2010) disorders through the regulation of melanosomes transfer from the melanocytes to the keratinocytes

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The specific reasons for the heterogeneity in most efficacy parameters remain unclear but are likely related to variations in dosages and follow‐up durations across the studies