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Chemical chaperones such as 4-phenylbutyrate (4-PBA) and tauroursodeoxycholic acid (TUDCA) demonstrate neuroprotection in TBI models: 4-PBA enhances ER folding capacity and attenuates CHOP/caspase signaling with cognitive benefit in injury paradigms (Yang et al., 2024)

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In addition, Src-dependent Cav-1 phosphorylation is a crucial process mediating caveolae-associated endocytosis and eNOS activation in vascular endothelial cells 24,25