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The bone resorption process OCs requires macrophage CSF and receptor-activated NF-κB ligand (RANKL) and consumes abundant ATP produced by glycolysis and OXPHOS

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To further elucidate the pathophysiological role of mitochondrial dysfunction and inform treatment development, future studies should integrate omics-based profiling with dynamic neuroimaging to map the spatiotemporal relationship between mitochondrial imbalance and affective symptoms