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Additionally, high glucose, hydrogen peroxide, and STZ induced increased intracellular ROS, decreased activity of the Nrf2-GPX4 pathway, and reduced mitochondrial membrane potential in Rin-5F cells (Frey et al., 2020

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Beyond airway cells and bacterial interactions, DHE-based investigations have indicated increased general intracellular superoxide in the pancreas of CF pigs, a finding linked to endothelial dysfunction within the CF context (O’Malley et al., 2022)