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A recent study has shown that Pd and diethyldithiocarbamate (DTC) shown an effective removal of acetamidomethyl (Acm) PG and the direct formation of a single disulfide bond in peptides with no side reaction 16
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In vitro studies show that Mst1, transcriptionally activated by the nuclear receptor NR4A, translocates to the nucleus, where it interacts with p53 to promote Drp1 gene expression and Drp1 phosphorylation at Ser616, thereby inducing excessive mitochondrial fragmentation
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