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The effect was even more pronounced in the indomethacin model, where only 4 out of 6 animals in the HRe-1 group developed ulcers, and the mean number and area of ulcers (1.3, 1.66 mm 2 ) were drastically lower than those in the control (14.3, 31.0 mm 2 ) and misoprostol (10.6, 26.33 mm 2 ) groups