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The results of cultured ECs and animal models of HHcy indicate that Hcy can injury ECs and cause endothelial dysfunction (60, 61)

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Similarly in patient 19 who exhibited a decrease in IGF-1 from −0.9 SD to −2.1 SD, TT at baseline was 148 ng/dL and increased to 157 ng/dL after 5 months of clomiphene therapy