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The most distinct feature of PCPGs is they often produce and secrete catecholamines including adrenaline, noradrenaline, and dopamine, among which the synthesis of adrenaline is catalyzed by phenylethanolamine N -methyltransferase (PNMT) and needs SAM as a co-substrate [115]

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Mice process compounds much faster than humans, pound for pound, which is exactly why naive scaling overstates safety