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Interaction with Melatonin Skin Cell Receptors The skin, an organ with an autonomous melatonin system, expresses both melatonin synthesis machinery and melatonin receptors, primarily MT1 and MT2

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The weight loss effect depends specifically on AMY1R and AMY3R activation, as confirmed by a study in eBioMedicine that showed cagrilintide lowers body weight through these specific receptor subtypes in the brainstem