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Notably, more than 95% of Kupffer cells expressed TIM4, a marker of embryonically-derived Kupffer cells 25 , indicating that repopulation by monocyte-derived macrophages (which are typically TIM4 − ) was minimal under these conditions (Supplementary Fig
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Less controversially, the second phase is likely caused by direct stimulation of L-cells by digested nutrients
This is particularly true during acute infections
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