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The composition of the cell growth medium and the fermentation variables such as temperature, pH, induction time, and inducer concentration are also essential for the prevention of protein aggregation, whereby a careful optimization improves the yield and quality of soluble protein production (Jana and Deb, 2005)

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They are highly expressed in the cytoplasmic and mitochondrial compartments of cardiomyocytes and represent an important defense mechanism within the heart [4, 7]