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further modified EcN to co-express IL-2 and leverage its inherent LPS production, which enhances IFN-γ secretion by cytotoxic T cells, while engineered IL-2 amplifies this effect by expanding effector T cell populations—creating a dual metabolite-cytokine synergy (300)

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One hypothesis for this finding is that multinutrients regulated immune responses and reduced the demand for pro-inflammatory factors, as has been shown for major depressive disorder (Kouba et al., 2024)