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Introduction Growth hormone (GH), also known as somatotropin, is an amino acid peptide that, together with prolactin (PRL) and human placental lactogen, belongs to the somatotropin family (Strobl and Thomas, 1994)

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Two models of GBM cells and an intracranial xenograft mouse model were used to study GBM cells ferroptosis induced by transfection of small interfering RNAs (siRNAs) targeting C5aR1 and treatment with PMX205 [33], a pharmacological inhibitor of C5aR1