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When given orally, vitamin C concentration in human plasma is tightly controlled by multiple mechanisms acting together: intestinal absorption, tissue accumulation, renal reabsorption and excretion, and potentially even the rate of utilization

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Capsule count:30 Capsules

Based on human BCRP ATPase activity where the formation of ADP was quantified as an indicator for either stimulation or inhibition of the transporter in presence of test compounds, mitragynine was reported as a potential substrate of the BCRP and could inhibit the transporter function with an IC 50 value of 359 μM (Wagmann et al., 2018)