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A similar peroxidase-mediated redox relay has been described for the mammalian Prx1, which accelerates oxidation of the apoptosis signaling kinase 1 (ASK1) via transient formation of a Prx1-ASK1 disulfide [111]
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Those who took Pycnogenol (1 mg/kg daily) for 4 weeks showed significant improvement in attention, visual-motor coordination, and concentration , and reduced hyperactivity, compared to placebo
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