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Design, Setting, and Participants A prospective follow-up study in 899 men and women who were free of dementia at baseline, had a median age of 76.0 years, and were followed up for a mean of 9.1 years for the development of all-cause dementia and Alzheimer disease

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These receptors, like the lipoprotein receptor related protein (LRP-1), normally allow essential substances like glucose, insulin and growth hormones to enter the brain