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Xenobiotic-Induced Oxidative Stress & Cellular Signaling – Reactive oxygen and nitrogen species generated by xenobiotic metabolism can cause DNA damage, protein oxidation, and lipid peroxidation if not adequately regulated

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Pirtobrutinib inhibits WT BTK (Y223) autophosphorylation with an IC 50 of 3.68 nM

Compared to Ascorbic Acid