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In a clinical trial, administration of 2600 mg of ALA to 18 patients just before kidney transplantation along with perfusion of the renal grafts with 600 mg of ALA 1 h before transplantation markedly reduced plasma creatinine level and severity of DGF, and prevented renal allograft rejection while increasing MDRD during the first 14 days after kidney transplantation compared to placebo-treated control group (18 patients) (Weber et al., 2017)

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although its level is not as high in Europe and North America, pollution is now making headlines in west and recently pollution level across continent of Africa has also increased significantly