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In the long term, ≤25–33% of patients with UC will require surgery if pharmacological treatments are not successful, or in the case of complications such as fistulae, stenosis, or abscesses (particularly in Crohn's patients) [9]

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PGRN acts as a novel regulator of mitochondrial homeostasis by facilitating mitophagy and mitochondrial biogenesis to prevent podocyte injury in diabetic nephropathy