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Inflammation and the Role of Eicosanoids Inflammation is triggered when the cells of the innate immune system detect infection or tissue injury The increased production of eicosanoids that is associated with inflammation is commonly triggered by activation of the innate immune system consisting of tissue resident macrophages and mast cells that become highly activated when they come into contact with either endogenous host-derived molecules, termed damage-associated molecular patterns ( DAMPs ) resulting from cellular trauma