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Known risks and side effects: Increased appetite, commonly reported and documented at a substantially higher rate on MK-677 than placebo (67% versus 36% of participants) in the Nass et al

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A 2015 Phase I/IIa randomized double-blind controlled trial in Movement Disorders enrolled 30 patients with Parkinson's disease randomized to 300 mg/day or 600 mg/day intranasal glutathione in three divided doses versus saline placebo for 3 months with a 1-month washout, and found that all groups met tolerability criteria with no substantial between-group differences in adverse events — a safety/tolerability signal rather than an efficacy demonstration