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Cervellini and colleagues have noted that persistent activation of the MAPK/ERK pathway in Schwann cells has stimulated myelination, but in the case of an excessive activation of this pathway de–myelination and de–differentiation of Schwann cells have occurred (Cervellini et al., 2018)

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[89] found that angiotensin II (Ang-II) induces endothelial dysfunction, vascular remodeling, and hypertension through NLRP3 inflammasome activation