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As a result, GATA-1-deficient mice do not develop eosinophils, and deletion of a specific GATA binding site of the mouse GATA-1 promoter (ΔdblGATA mice) results in strains of mice in which terminal differentiation of eosinophils is prevented.25,26 FOG-1 functions to antagonize GATA-1 activity and must be downregulated for eosinophil development to occur.19,27 Mice deficient in C/EBPα
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