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HRD1 is an endoplasmic reticulum (ER) membrane-associated E3 ubiquitin ligase involved in ER-associated degradation (ERAD)
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Clearly, although serum B12 is the most frequently used biomarker of B12 status, the marked variation in the literature for the reference limits and cutoffs said to be indicative of inadequate B12 status, make the diagnosis of B12 deficiency and the provision of prevalence estimates based on serum B12 alone challenging
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